Skip to main content
. 2005 Apr;73(4):2504–2514. doi: 10.1128/IAI.73.4.2504-2514.2005

TABLE 2.

Mortality recorded after intratracheal P. aeruginosa challenge of CF mice and BALB/c mice with the mucoid strain +QS (NH57388A), the nonmucoid strain −QS (NH57388B), and the nonmucoid strain +QS (NH57388C)a

Parameter Expt 1
Expt 2
Expt 3
Expt 4
CF mice (mucoid +QS NH57388A) BALB/c mice (mucoid +QS NH57388A) BALB/c mice (mucoid +QS NH57388A) BALB/c mice (nonmucoid −QS NH57388B) BALB/c mice (mucoid +QS NH57388A) CF mice (mucoid +QS NH57388A) CF mice (nonmucoid +QS NH57388C) CF mice (nonmucoid −QS NH57388B)
Mortality (no. of animals dying/total no. tested) at day:
    1 1/26 0/15 1/22 1/15 1/20 0/13 2/15 1/13
    2 3/26 0/15 1/22 1/15 1/20 2/13 3/15 0/13
    3 4/26 0/15 4/22 1/15 1/20 3/13 2/15 1/13
    4 4/26 0/15 3/22 0/15 1/20 0/13 1/15 0/13
    5 5/26 0/15 2/22 0/15 0/20 1/13 1/15 0/13
    6 0/26 0/15 1/22 0/15 0/20 0/13 0/15 1/13
    7 0/26 0/15 0/22 0/15 0/20 0/13 0/15 0/13
Total 17/26 0/15 12/22 3/15 4/20 6/13 9/15 3/13
Mortality (%) 65*** 0 55* 20 20 46 60** 23
95% Confidence interval 4-83 0-22 32-76 4-48 6-44 19-75 32-84 5-54
a

Expt 1, inoculum of 5 × 106 CFU/lung (bacteria were instilled with crude alginate); Expt 2, inoculum of 5 × 107 CFU/lung (bacteria were instilled with crude alginate); Expt 3, inoculum of 5 × 107 CFU/lung (bacteria were instilled with purified alginate); Expt 4, inoculum of 5 × 106 CFU/ml (bacteria were instilled with purified alginate).

b

* and **, P < 0.05 compared to strain NH57388B resuspended in culture supernatant (crude alginate [*]) or in purified alginate (**); ***, P < 0.001 compared to BALB/c mice.

HHS Vulnerability Disclosure