Fig. 4.

GV-971 modifies cytokine and chemokine levels in peripheral blood and cortical tissues. a Quantification of cytokine and chemokine concentrations in the serum of APPPS1-21 male mice treated with 160 mg/kg GV-971 or vehicle from the University of Chicago (n = 10–11). b Quantification of cytokine and chemokine concentrations in the serum of APPPS1-21 female mice treated with 160 mg/kg GV-971 or vehicle (n = 8–10). c, d Quantification of cytokine and chemokine concentrations in the serum of 5XFAD male mice treated with 100 mg/kg GV-971 or vehicle from Washington University in St. Louis (n = 12–13). e, f Quantification of cytokine and chemokine concentrations in the serum of 5XFAD female mice treated with 100 mg/kg GV-971 or vehicle (n = 9–12). g Quantification of cytokine and chemokine concentrations in the cortical tissue of 5XFAD male mice treated with 100 mg/kg GV-971 or vehicle (n = 12–13). Data presented as SEM. Significance determined using unpaired t-test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001