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. 2024 Feb 17;19:18. doi: 10.1186/s13024-023-00700-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — GV-971 treatment alters cerebral cortex transcriptome profiles in a sex-specific manner. a Gene overlap analysis demonstrating significant (P < 0.01) DEGs n = 728 in Male_Vehicle vs Male_GV, n = 426 DEGs in Female_Vehicle vs Female_GV and n = 730 DEGs in Male_Vehicle vs Female_Vehicle groups. Note only n = 23 DEGs that were common between GV-971-treated male and female groups compared with their respective vehicle-treated controls. b PCA plot. c Heatmap associated with lower DEGs (n = 436, P < 0.01) and higher DEGs (n = 294, P < 0.01) in Vehicle-treated female group compared with Vehicle-treated male group, note the sex-specific differences in DEGs between control male and female groups. Each column in an individual animal, n = 6 mice per group. d Heatmap associated with lower DEGs (n = 437, P < 0.01) and higher DEGs (n = 291, P < 0.01) in GV-971 treated male group compared with Vehicle-treated male group. Notice the female group columns exhibited no apparent differences for these genes. Each column is an individual animal, n = 6 mice per group. e GO biological processes, molecular functions, and KEGG pathways analysis based on the DEGs (P < 0.01) between vehicle-treated male and GV-971-treated male groups. Panel shows heatmap of top 20 pathways associated with lower DEGs in GV-971-treated male group compared with control