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. 2024 Feb 17;19:18. doi: 10.1186/s13024-023-00700-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Cytoscape and GSEA analyses using significantly altered genes (P < 0.01) in GV-971 treated male group compared with control. a Cytoscape analysis identified immunity pathway as a major impacted pathway associated with lower DEGs (P < 0.01) in GV-971-treated male compared with control. Most enriched genes are highlighted in darker shade. b Cytoscape analysis identified neuronal development pathway as a major impacted pathway associated with higher DEGs (P < 0.01) in GV-971 treated group compared with control. Most enriched genes are highlighted in darker shade. c GSEA enrichment results showed 9 significantly enriched gene sets out of 44 upregulated gene sets in Vehicle- treated male group compared with GV-971-treated male group