TABLE 3.
Levels of RNA transcription of esxA and esxB and cellular and secreted EsxA and EsxB for M. bovis strains with mutations at or near esxAa
| Strain | esxA (esat-6) RNA transcript | esxB RNA tran- script | EsxA (ESAT-6)
|
EsxB (CFP10)
|
||
|---|---|---|---|---|---|---|
| Cellular | Secreted | Cellular | Secreted | |||
| M. bovis wild type | ++ | ++ | ++ | +++ | ++ | +++ |
| WAg576 | ++ | ++ | +++ | ± | +++ | ± |
| WAg572 | ++ | ++ | +++ | − | +++ | ± |
| WAg540 | ++ | ++ | +++ | ± | +++ | ± |
| WAg573 | + | + | − | − | − | − |
| WAg574 | + | + | ± | − | + | − |
| WAg756ko | − | ++ | − | − | − | − |
| BCG | − | − | − | − | − | − |
| WAg578 | + | + | − | − | ++ | − |
| WAg567 | ++ | ++ | +++ | + | +++ | + |
a
Relative levels were recorded as high (+++), moderate (++), low (+), trace (±), or not detectable (−).