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. 2024 Feb 13;19:1451–1467. doi: 10.2147/IJN.S444009

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© 2024 Li et al.

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BEC-EVs and BMC-EVs administrations reduced BBB leakage and ameliorated neurological function in MCAo rats. (A) Schematic diagram of animal experimental procedure in MCAo rats. (B) DiI labeled BEC-EVs and BMSC-EVs were internalized by brain endothelial cells and neurons. Lectin was regarded as endothelial marker, and Tuj-1 was recognized as neurons marker. Original image Scale Bar: 200 µm. Enlarged image Scale Bar: 50 µm. (C) TTC staining of rat brain sections after EVs treatment, and relative quantification of brain infarct size (n=4). (D) Upper panel: Evans Blue brain leakage after EVs administration. Lower panel: Evans Blue leakage quantification (n=9). (E) Neurological function evaluation by Longa score (n=10). (F) Neurological function evaluation by mNSS score after EVs administration in MCAo rats (n=10). (G) Neurological function evaluation by corner test (n=6). (H) Neurological function evaluation by adhesive removal test (n=6). ***P < 0.001, **P < 0.01, *P < 0.05.