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. 2024 Feb 13;19:1451–1467. doi: 10.2147/IJN.S444009

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© 2024 Li et al.

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BEC-EVs and BMSC-EVs administrations inhibited Caveolin-1/CD147/ /VEGFR2 pathway in MCAo rats. (A) Western blotting of CD147, VEGFR2, VEGFA, and Caveolin-1 in brain microvessels. (B) Relative quantification of CD147, VEGFR2, VEGFA, and Caveolin-1 in brain microvessels (n=3). (C–E) Immunofluorescence staining of Caveolin-1, CD147, VEGFR2 in ischemic brain cortex. Scale bar: 200 µm. (F) Relative quantification of mean fluorescence intensity of Caveolin-1, CD147 and VEGFR2 (n=4). ***P < 0.001, **P < 0.01, *P < 0.05.