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. 2024 Feb 13;19:1451–1467. doi: 10.2147/IJN.S444009

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© 2024 Li et al.

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Caveolin-1/CD147/VEGFR2/MMP pathway played predominant role in the permeability of OGD-insulted BECs (A) Sketch of transwell assay in OGD-insulted BEC and the transfection of Caveolin-1 and CD147 siRNA. (B) Relative leakage OGD-insulted BECs monolayer after Caveolin-1 siRNA transfection (n=4). (C) Relative leakage OGD-insulted BECs monolayer after CD147 siRNA transfection (n=4). (D) Caveolin-1 and CD147 siRNA reduced MMP-2/9 activity evaluated by gelatin zymography in OGD-insulted BECs and relative quantification. Std: positive control of MMP standard sample. (E and F) Western blotting of CD147, Caveolin-1, VEGFR2, and VEGFA in OGD-insulted BECs after Caveolin-1 siRNA transfection and relative quantification (n=3). (G and H) Western blotting of ZO-1, Occludin, CD147, VEGFR2, Caveolin-1, and VEGFA in OGD-insulted BECs after CD147 siRNA transfection and relative quantification (n=3). ***P < 0.001, **P < 0.01, *P < 0.05.