Table 2.
Cryptococcosis Following Coronavirus Disease 2019
| Timing of Cryptococcal Infection Following COVID-19 | No. (%) |
|---|---|
| Days post-COVID-19 that Cryptococcus was diagnosed (n = 68), median (IQR) | 22 (9–42) |
| Symptoms of Cryptococcus | |
| Cough | 30 (43) |
| Fever | 26 (38) |
| Confusion | 20 (29) |
| Lethargy | 18 (26) |
| Headache | 17 (25) |
| Dyspnea | 17 (25) |
| Nausea | 6 (9) |
| Weakness | 5 (7) |
| Vomiting | 4 (6) |
| Vision changes | 3 (4) |
| None | 2 (3) |
| Unknown | 11 (16) |
| Confirmation of cryptococcal diseasea | |
| Serum CrAg performed | 54 (78) |
| Positive | 41 (59) |
| Blood cultures performed | 63 (91) |
| Positive | 30 (43) |
| CSF CrAg performed | 33 (47) |
| Positive | 13 (19) |
| CSF culture performed | 33 (47) |
| Positive | 9 (13) |
| Diagnosed by other culture | 16 (23) |
| BAL/tracheostomy aspirate | 10 (14) |
| Sputum | 5 (7) |
| Pleural effusion | 1 (1) |
Data are presented as No. (%) unless otherwise indicated.
Abbreviations: BAL, bronchoalveolar lavage; COVID-19, coronavirus disease 2019; CrAg, cryptococcal antigen; CSF, cerebrospinal fluid; IQR, interquartile range.
aDiagnosis confirmed on the basis of data that were returned postmortem (n = 11).