Table 4.

Treatment strategies

Remission induction	Remission maintenance
Chemotherapy with R + CHOP by diagnosis of a non-Hodgkin lymphoma (R; Rituximab, C; Cyclophosphamide, H; Doxorubicin, O; Vincristine, P; Prednisone)	Prednisone 1.5 mg per day
Steroid pulse (1000 mg per day for 3 days) followed by oral Prednisone 70 mg/day with tapering schedule + parallel plasmapharesis (7x) + parallel initiation Cyclophosphamide (every four weeks, for 6 times) + parallel intravenous immunoglobuline administration ( every four weeks, for 6 times (95 g each over 3–4 days) + parallel initiation Tacrolimus 9 mg 1–0–1 per day	Tacrolimus 7.5 mg 1–0–1 (Target serum level: 10 µg/L)
Steroid pulse followed by oral Prednisone with tapering schedule + parallel Mycophenolate mofetil switch Azathioprine and Hydroxychloroquine + Tacrolimus topically	Azathioprine 50 mg 1–0–1 Hydroxychloroquine 200 mg 1–0–0 Tacrolimus topically
oral Prednisone 50 mg/day with tapering schedule + parallel initiation Cyclophosphamide (every four weeks, for 6 times) + prostaglandine intravenous + parallel initiation Tacrolimus 4 mg 1–0–1 per day	Tacrolimus 4 mg 1–0–1 (Target serum level: 10 µg/L) Prednisone 4 mg per day
Steroid pulse (500 mg per day for 3 days) followed by oral Prednisone 80 mg/day with tapering schedule + parallel plasmapharesis (5x) + parallel initiation Cyclophosphamide (every four weeks, for 6 times) + parallel initiation Tacrolimus 2 mg 1–0–1 per day	Tacrolimus 2.5 mg 1–0–1 Prednisone 5 mg per day Rituximab 1000 mg every six month
Steroid pulses (2015–2018) followed by Mycophenolate mofetil followed by Tocilizumab followed by Cyclosporine A	Cyclosporine A 150 mg 1–0–1
Oral Prednisone and Methotrexate switch Methotrexate + Azathioprine + Hydroxychloroquine followed by oral Prednisone + prostaglandine intravenous + intravenous immunoglobuline (Proof of MDA5) Dose increase oral Prednisone 40 mg/day with tapering schedule + parallel initiation Cyclophosphamide (every four weeks, for 6 times) followed by R ituximab (every six month) + parallel initiation Tacrolimus 2 mg 1–0–1 per day	Tacrolimus 2 mg 1–0–1 (Target serum level: 10 µg/L) Hydroxychloroquine 200 mg 1–0–1 Prednisone 5 mg per day Rituximab 1000 mg every six month
Chemotherapy with Dnr/AraC/Midostaurin by diagnosis of acute myeloid leukemia (Dnr; Daunorubicin, AraC; Cytarabin) (Proof of MDA5) Recommendation to start Tacrolimus orally, patient denied	Watch and wait