Table 3.
ORs and 95% CIs for depressive symptoms in relation to AGXT2 polymorphisms
| SNPa | Genotype | Cases n (%) | Controls n (%) | Crude OR (95% CI) | Adjusted OR (95% CI)b |
|---|---|---|---|---|---|
| rs37370 | (N = 280) | (N = 2029) | |||
| CC | 52 (18.6) | 419 (20.7) | 1.00 | 1.00 | |
| CT | 133 (47.5) | 972 (47.9) | 1.10 (0.79–1.56) | 1.08 (0.77–1.54) | |
| TT | 95 (33.9) | 638 (31.4) | 1.20 (0.84–1.73) | 1.20 (0.84–1.74) | |
| rs180749 | (N = 280) | (N = 2034) | |||
| GG | 5 (1.8) | 100 (4.9) | 1.00 | 1.00 | |
| GA | 89 (31.8) | 664 (32.7) | 2.68 (1.17–7.75) | 2.83 (1.23–8.24) | |
| AA | 186 (66.4) | 1270 (62.4) | 2.93 (1.30–8.38) | 3.10 (1.37–8.92) | |
| rs16899974 | (N = 280) | (N = 2033) | |||
| CC | 71 (25.4) | 561 (27.6) | 1.00 | 1.00 | |
| CA | 144 (51.4) | 1047 (51.5) | 1.09 (0.81–1.48) | 1.10 (0.81–1.50) | |
| AA | 65 (23.2) | 425 (20.9) | 1.21 (0.84–1.73) | 1.28 (0.89–1.85) |
aAGXT2 SNPs, rs37370 (C__1018750_1_), rs180749 (C__1018735_1_), and rs16899974 (C__25742181_10), were genotyped using the prestandardized and experimentally validated TaqMan SNP genotyping assay.
bAdjusted for age, sex, smoking status, alcohol consumption, leisure time physical activity, education, body mass index, hypertension, dyslipidemia, and diabetes mellitus.
Bold text indicates statistical significance
CES-D Center for Epidemiologic Studies Depression Scale, CI confidence interval, OR odds ratio