Table 4.
Haplotype analysis of three AGXT2 polymorphisms in relation to depressive symptoms
| Haplotypea | Frequency n (%) | Crude OR (95% CI)b | |
|---|---|---|---|
| Cases (2N = 560) | Controls (2N = 4068) | ||
| CGC | 9 (1.6) | 66 (1.6) | 0.99 (0.43–2.01) |
| CAC | 73 (13.0) | 621 (15.3) | 0.83 (0.63–1.08) |
| CAA | 155 (27.7) | 1117 (27.5) | 1.01 (0.82–1.24) |
| TGC | 53 (9.5) | 550 (13.5) | 0.67 (0.49–0.90) |
| TGA | 37 (6.6) | 232 (5.7) | 1.17 (0.79–1.68) |
| TAC | 151 (27.0) | 934 (23.0) | 1.24 (1.01–1.52) |
| TAA | 82 (14.6) | 532 (13.1) | 1.14 (0.88–1.47) |
Rare haplotypes (frequency less than 1% in either cases or controls) were deleted. Bold text indicates statistical significance
CI confidence interval, OR odds ratio
aHaplotype order is rs37370, rs180749, and rs16899974
bCrude OR for each haplotype is relative to all other haplotypes combined