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. 2024 Feb 17;15:1470. doi: 10.1038/s41467-024-45855-2

Fig. 6. Mucosal host–microbe interactions depend on individual dysbiotic status.

Fig. 6

A PCA of mucosal 16 S rRNA sequencing data shows that degree of mucosal dysbiosis scores. B Dysbiosis scores were generally higher among patients with CD and UC compared to non-IBD controls (Spearman correlation test). C Key examples of individual gene–bacteria interactions that demonstrate a directional shift upon dysbiotic samples (higher dysbiosis 90–100%) as compared to patients with eubiotic samples (lower dysbiosis scores 0–90%) in IBD (linear regression model, t test, adjusted P < 0.05). Mucosal Lachnospiraceae bacteria positively associate with the expression of the PLAUR, CXCL17, IL1RN and S100A8 genes. CD, Crohn’s disease. PC, principal component. UC, ulcerative colitis. r, Spearman correlation coefficient. The shaded areas represent the 95% confidence intervals for predictions from a linear model. The Source data are provided as a Source Data file.