Fig. 8. The model can be adjusted to predict mitochondrial protein-rich ribosome composition.

All parameters used for the simulation of mitochondria are the same as for E. coli in glucose minimal media, except a fraction of rPs can be imported for free from the cytoplasm and does not have to be synthesized. For simplicity, we assumed that 1/3 of rP are imported. (In reality, almost all rP are imported, but mitochondria make additional proteins to provide energy for the whole cell). Panels (a–c) represent three types of rRNA degradation. a No cooperativity of rPs. b Weak cooperativity of rPs. c Strong cooperativity of rPs.