Fig. 3. Reduction of ZIKV-induced inflammation and pathology in the placenta.

At 14 dpi, the placentas at comparable gestational day ~89 were fixed and stained with hematoxylin and eosin. The representative images of the placentas of unvaccinated (a–c), vaccinated (d–f), and virus-free naive (g–i) dams. The top row represents the whole placenta, middle row represents decidua, and the bottom row represents trabecular (villous) areas. Decidua polymorphonuclear infiltration is indicated with an arrow. Asterisks indicate fibrin deposition. Arrow heads indicate necrotic bodies in the extramedullary hematopoiesis. Scale bars in (a), (d) and (g) are 500 μm. Sale bars in middle and bottom rows are 100 μm and 20 μm in the inserts.