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Protection by IL-12 requires CD8 cells. C57BL/6 wild-type mice and CD8−/− (KO) mice were inoculated i.n. with either PBS vehicle or 0.5 μg of IL-12 24 h before i.n. infection with 10,000 CFU of F. tularensis LVS. Survival was monitored. There were eight mice per group.
