Table 3. Multivariable analysis of CVD, IS and PVD for PPIs and H2RAs users by unadjusted, stratified Cox-PH, and propensity score matched COX-PH models regarding grace period = 90 days.

Models	Cardio vascular diseases (CVD)1		Ischemic stroke (IS)2		Peripheral vascular diseases (PVD)3
	Crude HR [95% CI]	Adjusted HR [95% CI]	Crude HR [95% CI]	Adjusted HR [95% CI]	Crude HR [95% CI]	Adjusted HR [95% CI]
Unadjusted	1.73 [1.47–2.04]	–	4.01 [2.77–5.82]	–	16.25 [4.03–65.62]	–
On-treatment: stratified cox-PH adjusted for baseline covariates*	–	1.16 [0.94–1.42]	–	1.92 [1.24–2.97]	–	5.49 [1.22–24.61]
1:1 Propensity score-matched (PSM)**	–	1.76 [1.40–2.20]	–	3.53 [2.21–5.64]	–	17.07 [13.82–76.25]

Notes:

1* Model: adjusted for alcohol abuse, diabetes and diastolic blood pressure, stratified by clopidogrel, baseline age (≤60/>60), NSAIDs, steroids, number of hospital visits (≤2, >2), systolic blood pressure (<80/≥80), Charlson’s comorbidity index (≤1, >1) index years, and dyslipidemia.

2* Model: adjusted by clopidogrel, NSAIDs, diastolic blood pressure (<120/≥120), and alcoholic abuse, stratified by baseline age, index years, Charlson’s comorbidity index (≤1, >1), dyslipidemia, diabetes, steroids, number of hospital visits (≤2, >2), systolic blood pressure (<80/>=80).

3* Model: adjusted by number of hospital visits (≤2,>2), systolic blood pressure (<80/≥80), steroids, diastolic blood pressure (<120/≥120), and alcoholic abuse, stratified by baseline age (≤60/>60), index years, Charlson’s comorbidity index (≤1, >1), dyslipidemia, diabstes, clopidogrel, NSAIDs.

1–3** Model: Propensity score matching by sex, baseline age (≤60/>60), index years, diabetes, dyslipidemia, rheumatoid arthritis, Charlson’s comorbidity index (CCI), NSAID, Clopidogrel, Steroids, Diuretics, number of hospital visits, baseline systolic blood pressure and diastolic blood pressure.