FIG. 1.

Specific antibody (Ab) responses in the female genital tracts of macaques after CT immunization by various routes. Data are expressed as geometric mean numbers (bars) and individual values (circles) for CT-specific IgA (closed symbols) and IgG (open symbols). (A) CT-specific titer increases in cervicovaginal washes after three or four enteric, vaginal, or rectal administrations of CT. Some values are missing due to insufficient material for total IgA determinations. Titer increases are defined as the postbooster titer divided by the prepriming titer. (B) CT-specific ASC responses in the cervicovaginal mucosa after four systemic, vaginal, or rectal immunizations with CT. The dashed line denotes the limit (30 ASC per 10⁶ MNC) below which net values were considered negative (99% confidence interval). N.D., not determined.