TABLE 3.
Survival of mice after administration of Cy
| P. aeruginosa strain | No. of surviving mice/total no. of infected mice at a Cy dose (in mg/kg) of:
|
||||
|---|---|---|---|---|---|
| 50 | 75 | 100 | 125 | 150 | |
| PAO1 | 4/4 | 4/4a | 4/4a | 0/4 | 0/4 |
| PAO1 ExoU+ | 4/4 | 0/4a | 0/4a | 0/4 | 0/4 |
| PAK | 4/4 | 0/4 | 0/4 | 0/4 | 0/4 |
| PAK ExoU+ | 4/4 | 0/4 | 0/4 | 0/4 | 0/4 |
| 15921 pUCP19 | 4/4 | 19/20b | 0/4 | 0/4 | 0/4 |
| 15921 ExoU+ | 4/4 | 14/20b | 0/4 | 0/4 | 0/4 |
| PA103 | 4/4 | 0/4 | 0/4 | 0/4 | 0/4 |
| PA14 | 4/4 | 0/4 | 0/4 | 0/4 | 0/4 |
a
P = 0.03 by Fisher's exact t test comparing mice given the same dose of Cy and colonized by isogenic strains with and without ExoU expression.
b
P = 0.09 by Fisher's exact t test comparing mice given 75 mg of Cy/kg and colonized by isogenic strains with and without ExoU expression.