Tabla 1.
Total (n=109) | HC positivo (n=22) | HC negativo (n=87) | p | |
---|---|---|---|---|
Datos demográficos | ||||
Edad (años) [media (DE)] | 83,5 (5,5) | 83,1 (5,6) | 83,8 (5,5) | 0,282 |
Varón [n(%)] | 64 (58,7) | 12 (54,5) | 52 (59,8) | 0,657 |
Comorbilidad | ||||
Cardiovascular [n(%)] | 72 (66,1) | 13 (59,1) | 59 (67,8) | 0,440 |
Respiratoria [n(%)] | 42 (38,5) | 7 (31,8) | 35 (40,2) | 0,469 |
Inmunodeficiencia [n(%)] | 14 (l2,s) | 3 (13,6) | 11 (12,6) | 0,901 |
Diabetes [n(%)] | 29 (26,6) | 5 (22,7) | 24 (27,6) | 0,645 |
Enfermedad renal [n(%)] | 22 (22,2) | 5 (22,7) | 17 (19,5) | 0,739 |
Enfermedad hepática [n(%)] | 8 (7,3) | 3 (13,6) | 5 (5,7) | 0,205 |
Cáncer [n(%)] | 40 (36,7) | 11 (50,0) | 28 (33,3) | 0,275 |
Enfermedad del SNC [n(%)] | 35 (32,1) | 3 (13,6) | 32 (36,8) | 0,038 |
Otra [n(%)] | 41 (37,6) | 8 (36,4) | 33 (37,9) | 0,892 |
Índice de Charlson [media (DE)] | 3,2 (1,8) | 3,3 (1,9) | 3,2 (1,7) | 0,601 |
Signos vitales | ||||
Temperatura (°C) [mediana (RIC)] | 38 (37-38,2) | 38,3 (38-39) | 38 (37,2-38,2) | 0,003 |
Frecuencia cardiaca (lpm) [mediana (RIC)] | 90 (78-106) | 95 (80-110) | 90 (75-105) | 0,020 |
Frecuencia Resp. (rpm) [mediana (RIC)] | 18 (16-22) | 18 (16-23) | 20 (17-22) | 0,483 |
PAS (mm Hg) [mediana (RIC)] | 130 (110-147) | 118 (99-140) | 130 (108-147) | 0,194 |
PAD (mm Hg) [mediana (RIC)] | 65 (56-77) | 61 (55-67) | 67 (56-77) | 0,129 |
PAM (mm Hg) [mediana (RIC)] | 86 (76-99) | 82 (69-93) | 87 (77-99) | 0,095 |
Sat O2 (%) [mediana (RIC)] | 94 (91-96) | 95 (93-96) | 93 (90-95) | 0,752 |
Variables analíticas | ||||
Leucocitos (x103/mm3) [mediana (RIC)] | 11,1 (7,6-15,5) | 10,7 (5,9-15,4) | 11,6 (8-15,6) | 0,375 |
Trombocitos (x103/mm3) [mediana (RIC)] | 188 (134-262) | 157 (116-221) | 189 (141-270) | 0,036 |
Urea (mg/dL) [mediana (RIC)] | 47 (27-70) | 50 (35-61) | 51 (33-74) | 0,287 |
Creatinina (mg/dL) [mediana (RIC)] | 1 (0,9-1,5) | 1,2 (1-1,5) | 1 (0,9-1,4) | 0,629 |
Bilirrubina (mg/dL) [mediana (RIC)] | 1,0 (0,5-2,1) | 0,9 (0,7-1) | 1 (0,5-2) | 0,785 |
Tipo de infección | ||||
Respiratoria [n(%)] | 49 (45,0) | 8 (36,4) | 41 (47,1) | 0,365 |
Gastrointestinal [n(%)] | 10 (9,2) | 1 (4,5) | 9 (10,3) | 0,400 |
Intraabdominal [n(%)] | 13 (11,9) | 5 (22,7) | 8 (9,2) | 0,080 |
Urinaria [n(%)] | 29 (26,6) | 6 (27,3) | 23 (26,4) | 0,937 |
Catéter [n(%)] | 4 (3,7) | 2 (9,1) | 2 (2,3) | 0,130 |
IPPB [n(%)] | 4 (3,7) | 1 (4,5) | 3 (3,4) | 0,807 |
Foco desconocido [n(%)] | 6 (5,5) | 1 (4,5) | 5 (5,7) | 0,825 |
Otro [n(%)] | 8 (7,3) | 3 (13,6) | 5 (5,7) | 0,205 |
Escalas clínicas | 6 (1.9) | 3 (2.7) | 3 (1.4) | 0.423 |
qSOFA [mediana (RIC)] | 1 (0-2) | 1 (0-2) | 1 (0-1) | 0,082 |
NEWS score [mediana (RIC)] | 5 (3-8) | 6(4-10) | 7 (4-8) | 0,080 |
SOFA score [mediana (RIC)] | 2 (0-4) | 2 (1-3) | 2 (0-4) | 0,858 |
Biomarcadores | ||||
Proteína C reactiva (mg/dL) [mediana (RIC)] | 9,1 (3-17,4) | 6,7 (3,3-12,5) | 9,1 (3-16,3) | 0,664 |
Lactato (mg/dL) [mediana (RIC)] | 1,6 (1,2-2,5) | 2 (1,2-2,9) | 2,2 (1,5-3,1) | 0,014 |
Procalcitonina (mg/dL) [mediana (RIC)] | 0,6 (0,1-2) | 3,7 (1-13,5) | 1,2 (0,3-6,5) | <0,001 |
MR-proADM (mg/dL) [mediana (RIC)] | 1,6 (1,2-2,7) | 2,8 (2-3,8) | 2,2 (1,5-3) | <0,001 |
Indicadores de resultado | ||||
Estancia media (días) [media (DE)] | 11,8 (11,4) | 12,1 (12,0) | 11,7 (11,2) | 0,336 |
Ingreso en UCI [n(%)] | 5 (4,6) | 1 (4,5) | 4 (4,6) | 0,992 |
Reingreso [n(%)] | 6 (5,5) | 2 (9,1) | 4 (4,6) | 0,409 |
Mortalidad [n(%)] | 10 (9,2) | 0 (0) | 10 (11,5) | 0,095 |
DE: desviación estándar; RIC: rango intercuartil; SNC: Sistema Nervioso Central; PAS: presión arterial sistólica; PAD: presión arterial diastólica; PAM: presión arterial media; Sat O2: saturación basal de oxígeno; IPPB: infección de piel y partes blandas; qSOFA: quick Sequential Organ Failure Assessment; SOFA: Sepsis related Organ Failure Assessment; NEWS: National Early Warning Score