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Sequence alignment of the gasdermin NTD-CTD linker region. Selected gasdermin family members from human and mouse are shown with identical and conserved residues, cleavage sites by caspases and other proteases marked as noted. The F240 residue in hGSDMD was shown to be crucial for oligomerization and pore formation. Among the hGSDMB isoforms, only three harbor the conserved Phe residue.
