Table 7.
Analyte Concentrations in Plasma of Adolescent (Postnatal Day 37; n=5) Male and Female Mice 1 H After Intraperitoneal Administration of Vehicle (5:95 Tween80/Saline, 5:95, v/v), THC (5 mg/kg), HOE (100 mg/kg), or HOE:THC (100/5 mg/kg)
| Peak | Analyte | VEH |
THC (5 mg/kg) |
HOE (100 mg/kg) |
HOE:THC 20:1 |
||||
|---|---|---|---|---|---|---|---|---|---|
| Males (ng/g) | Females (ng/g) | Males (ng/g) | Females (ng/g) | Males (ng/g) | Females (ng/g) | Males (ng/g) | Females (ng/g) | ||
| 1 | 11-OH-THC | ND | ND | 106.82 | 188.37# | ND | ND | 123.56 | 188.16 |
| 2 | 11-COOH-THC | ND | ND | 17.93 | 18.93 | ND | ND | 17.12 | 17.30 |
| 3 | CBD | ND | ND | ND | ND | 68.53 | 62.23 | 59.61 | 51.18 |
| 4 | THC | ND | ND | 261.03 | 198.48 | ND | ND | 307.35 | 307.57 |
| 5 | Anandamide | 2.79 | 3.42 | 2.94 | 3.60 | 2.72 | 3.68 | 3.10 | 3.31 |
| 6+7 | 2-AG | 9461.22 | 12,322.85 | 8743.13 | 11,212.47 | 10,994.10 | 10,169.30 | 11,795.73 | 10,653.38 |
| 8 | VEA | 4.10 | 5.92# | 5.34 | 5.53 | 4.64 | 5.47 | 5.54 | 5.41 |
| 9 | OEA | 1.81 | 3.17## | 2.19 | 2.29 | 2.17 | 2.18* | 3.28* | 1.96*,## |
| 10 | PEA | 80.41 | 134.14# | 88.91 | 87.85 | 81.85 | 99.99 | 139.16* | 85.85# |
*
Denotes significance compared with vehicle. #Denotes significance by sex. * or #p<0.05, or ##p<0.01, two-way ANOVA with Bonferroni post hoc analysis. The standard error of the mean was in all cases ≤30% and was omitted for clarity.