Table 5.

ROC analysis for predicting the absence of biochemical remission when using preoperative PRL level as a diagnostic marker.

Parameter	All patients (n = 109)	Micro (n = 75)	Macro (n = 34)
Analysis after 1 month
Cut-off value	>299.5	>200	>345
Sensitivity, %	67.5	44.2	70.5
Specificity, %	66.6	82.6	88.2
NPV, %	77.9	85.1	85.7
PPV, %	54.0	39.5	75.0
Diagnostic accuracy, %	66.9	56.0	79.4
AUROC	0.680	0.616	0.744
95% CI	0.577–0.783	0.487–0.745	0.561–0.927
P (AUROC)	0.002	0.112	0.015
Analysis after 12 months
Cut-off value	>351	>210	>396
Sensitivity, %	60.0	53.3	90.0
Specificity, %	71.4	36.6	62.5
NPV, %	85.7	75.8	93.7
PPV, %	38.4	17.3	50.0
Diagnostic accuracy, %	68.8	40.0	70.5
AUROC	0.599	0.477	0.725
95% CI	0.459–0.738	0.293–0.660	0.558–0.892
P (AUROC)	0.136	0.781	0.041

NPV, negative predictive value; PPV, positive predictive value; AUROC, area under ROC-curve, 95% CI—95% confidence interval for AUROC.