TABLE 3.

Summary of different electrospun nanofibre scaffolds in the treatment of diabetic foot.

Double-fluid electrospinning		Multifluid electrospinning
Coaxial electrospinning	Side-by-side electrospinning	Three-fluid electrospinning
i. The drug is loaded into the core layer, and the drug is effectively protected from the external environment through the shell layer	i. Both sides of the polymer material and the drug are in direct contact with the outside world	Triaxial electrospinning is an improved process based on coaxial and juxtaposition electrospinning, which share their common advantages and are capable of constructing more complex drug controlled release systems
ii. By adjusting the composition and thickness of the fibres of the core-shell layer, the function of controlling the slow release of the drug is achieved
iii. Encapsulate different drug molecules in the core-sheath layer separately to prepare a multistage multi-effect drug release system	ii. It is able to constitute a dual-drug biphasic release drug release system, which helps the drug to be released rapidly
iv. The non-spinable polymer can be used as the core layer and the spinnable polymer as the shell layer, so that the shell layer can drive the core layer to electrospin, and the non-spinable polymer nanofibres can be prepared
i. At best, nanofibres capable of controlled release of two drugs have been prepared, which does not fully satisfy more complex and difficult therapeutic requirements	i. It is difficult to achieve the slow drug release effect of coaxial electrospinning	The preparation process is very difficult and requires a level by level modulation of parameters, with all the polymers and drugs affecting the preparation
ii. The preparation process is more complex and the parameters are more difficult to regulate compared to single-fluid electrospinning	ii. Similarly, juxtaposition electrospinning does not meet more complex and difficult therapeutic needs. It is also more complicated in the preparation process