Fig. 9.

Cell death induced on cancer cells after NIR treatment regimens. A) Schematic representation of the design of the experiments for apoptosis and necroptosis in the t3 NIR regimen. Caspase- or RIPK1-inhibitors were added three times into the wells at final concentrations of 20 μM before each NIR irradiation. B) Schematic representation of the design of the experiments for apoptosis and necroptosis in the NF NIR regimen. Caspase- or RIPK1-inhibitors were added once into the wells at final concentrations of 20 μM before NIR irradiation. C) Percentage of different types of cell death induced by NIR on mouse mammary tumor. D) Percentage of different types of cell death induced by NIR on mouse mammary tumor. ***p < 0.001 ANOVA and Turkey post-hoc test.