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. 2024 Jan 23;300(3):105674. doi: 10.1016/j.jbc.2024.105674

FigureĀ 9.

FigureĀ 9

Contributions of conserved residues to the Hv1 VSD energy landscape. Previous study showed that increasing the hydrophobicity of residue at position F150 (green arrow) stabilizes the resting state relative to active state. Present study indicates that increasing the size of the side chain at position W207 (blue arrow) is essential to control Hv1 VSD energy barrier. VSD, voltage-sensing domain.