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| |||||
|---|---|---|---|---|---|
| Entry | β-lactone | 11 (mol%) | Temp. (°C) | Yield (%) | % ee |
| 1 | (RS)-4 | 10 | −10 | 28 | 80 (S) |
| 2 | (RS)-4 | 10 | −20 | 18 | 78 (S) |
| 3 | (RS)-4 | 20 | 0 | 90 | 74 (S) |
| 4 | (RS)-4 | 5 | 0 | 84 | 68 (S) |
| 5 | (RS)-4 | 10 | 0 | 71 | 72 (S) |
| 6 | (S)-4 | 10 | 0 | 71 | 76 (S) |
| 7 | (R)-4 | 10 | 0 | 67 | 66 (S) |
