TABLE 1.
General characteristics of the subjects included from the two study cohorts
| SAILS cohort | SAIL cohort | SAILS versus SAIL p-value | ||||||||
| Overall (n=131) | Non-OSA (n=43) | Mild OSA (n=58) | Moderate-to-severe OSA (n=30) | p-value | Overall (n=39) | Non-OSA or mild OSA (n=19) | Moderate-to-severe OSA (n=20) | p-value | ||
| Female | 67 (51.1) | 27 (62.8) | 28 (48.3) | 12 (40.0) | 0.134 | 19 (48.7) | 13 (68.4) | 6 (30.0) | 0.038 | 0.933 |
| Age, years | 62±6 | 61±6 | 62±5 | 63±6 | 0.206 | 68±11 | 67 (55–69) | 70 (62–78) | 0.129 | 0.004 |
| BMI, kg·m−2 | 27.6±4.5 | 25.8±4.7 | 28.6±4.4¶ | 28.5±3.6# | 0.004 | 27.7±4.5 | 24.9 (21.5–27.4) | 28.8 (26.7–31.1) | 0.003 | 0.593 |
| Visceral fat, % | 11.1±4.2 | 9.0±4.4 | 12.0±3.7¶ | 12.4±3.7¶ | <0.001 | 11.4±5.8 | 7.5 (5.0–10.0) | 13.0 (11.0–18.0) | 0.002 | 0.755 |
| Free-fat mass, % | 33.2±9.8 | 31.9±10.9 | 34.7±9.5 | 32.1±8.5 | 0.286 | 33.2±9.0 | 34.5 (31.0–42.0) | 30.5 (28.5–39.0) | 0.294 | 0.966 |
| Waist/hip ratio | 0.97±0.09 | 0.94±0.09 | 0.98±0.09 | 1.01±0.07¶ | 0.007 | 0.94±0.09 | 0.88 (0.79–0.97) | 1.00 (0.95–1.04) | 0.667 | 0.428 |
| Neck perimeter, cm | 38±4 | 36±3 | 38±4¶ | 39±5¶ | <0.001 | 38±4 | 35 (34–37) | 39 (38–43) | 0.001 | 0.789 |
| Pack-years | 48±18 | 43±13 | 51±21 | 49±18 | 0.073 | 46±31 | 38 (30–60) | 49 (25–72) | 0.592 | 0.804 |
| COPD previous diagnosis | 61 (46.9) | 26 (60.5) | 20 (35.1) | 15 (50.0) | 0.116 | 18 (46.2) | 8 (42.1) | 10 (50.0) | 0.863 | 0.890 |
| AHI, events·h−1 | 10.8±11.2 | 2.7±1.5 | 9.0±2.6+ | 26.1±13.9+,## | <0.001 | 24.3±21.6 | 5.7 (3.5–11.4) | 35.1 (22.5–42.9) | <0.001 | 0.001 |
| Supine AHI, events·h−1 | 22.8±22.4 | 6.2±6.7 | 21.2±17.1+ | 49.5±20.9+,## | <0.001 | 33.8±27.3 | 8.7 (2.8–19.0) | 47.4 (31.8–72.7) | <0.001 | 0.015 |
| Desaturation index, events·h−1 | 10.5±11.2 | 2.5±1.7 | 8.7±3.2+ | 25.2±14.1+,## | <0.001 | 25.6±23.2 | 5.0 (3.4–7.8) | 35.2 (27.9–49.7) | <0.001 | 0.001 |
| tSaO2<90%, % | 23.0±30.3 | 17.2±26.7 | 25.6±34.5 | 26.7±26.4 | 0.299 | 23.6±29.9 | 1.0 (0.1–7.8) | 16.3 (4.6–42.5) | <0.001 | 0.916 |
| Mean SaO2, % | 91±2 | 91±2 | 91±3 | 90±2 | 0.327 | 91±3 | 92 (91–93) | 92 (90–93) | 0.158 | 0.824 |
| Minimum SaO2, % | 83±5 | 86±3# | 83±4 | 81±5+,§ | <0.001 | 81±8 | 86 (83–89) | 82 (77–84) | 0.002 | 0.110 |
| Central apnoea index, events·h−1 | 0.5±1.5 | 0.1±0.2 | 0.3±0.6 | 1.5±2.9+,ƒ | <0.001 | 2.5±7.3 | 0 (0–0.1) | 1.3 (0.3–2.3) | <0.001 | 0.126 |
| Snoring, % | 20.2±18.2 | 11.4±11.2 | 22.9±19.2¶ | 27.6±20.0+ | <0.001 | 18.5±17.9 | 9.7 (3.4–19.0) | 17.9 (7.5–29.7) | 0.192 | 0.631 |
Data are presented as n (%) or mean±sd, unless otherwise stated. BMI: body mass index; AHI: apnoea–hypopnoea index; SaO2: arterial oxygen saturation; tSaO2<90%: recording time with SaO2 <90%. Comparisons by ANOVA with Bonferroni post-hoc test, Mann–Whitney test or Chi-squared test with Fisher correction. #: p<0.05 versus non-OSA group; ¶: p<0.01 versus non-OSA group; +: p<0.001 versus non-OSA group (in SAILS cohort). §: p<0.05 versus mild OSA; ƒ: p<0.01 versus mild OSA; ##: p<0.001 versus mild OSA (in SAILS cohort).