Table 2.

Comparison of the SRI-4 and BICLA composite response indices

Components	SRI-4	BICLA
SLEDAI	Main driver of improvement in SRI-4 Improvement of 4 points or more	No worsening of the total SLEDAI-2K score from baseline
BILAG	No worsening with no new A score and/or ≤2 new B scores	Main driver of improvement in BICLA BILAG scores improve from A to B/C/D for all items with A scores or from B to C/D for all items with B scores AND No worsening with no new A score and/or ≥2 new B scores
PGA	PGA does not worsen by 0.3 points or more (10% or more)	PGA does not worsen by 0.3 points or more (10% or more)
Treatment failure criteria	N/A	No treatment failure (defined as non-protocol treatment or premature discontinuation of study treatment)

BICLA, BILAG-based Combined Lupus Assessment; BILAG, British Isles Lupus Assessment Group; N/A, not available; PGA, Physician Global Assessment; SLEDAI-2K, SLE Disease Activity Index 2000; SRI-4, SLE Responder Index-4.