TABLE 2:

Buprenorphine course descriptions

	All Buprenorphine Courses		Course Active 7/31/2019		Discontinued Courses
	Frequency	%	Frequency	% (row)	Frequency	% (row)
Number of Courses	63929	100	15132	24	48797	76
Number of patients	40431		15132		30817
Number of Deaths (by the end of study)	5572		55		5517*
Total Follow up time (to the last VA visit or death)
	Mean (std)	Median (IQR)	Mean (std)	Median (IQR)	Mean (std)	Median (IQR)
Drug Course Duration (days)	461 (729)	158 (38–538)	1009 (1055)	619 (203–1496)	291 (478)	106 (28–329)
Drug Course Duration (days) **	460 (729)	157 (37–537)	1008 (1055)	618 (202–1495)	290 (478)	105 (27–328)
Proportion of Days Covered (PDC)	0.90 (0.15)	0.96 (0.88–1)	0.93 (0.11)	0.97 (0.91–0.99)	0.89 (0.16)	0.96 (0.86–1)
Medication Possession Ratio (MPR)	0.96 (0.21)	1 (0.92–1.01)	0.98 (0.14)	1 (0.96–1.02)	0.95 (0.22)	1 (0.90–1.01)
Average Prescribed Dose (mg per day)	13.44 (6.50)	13.66 (8–16.51)	14.88 (6.42)	15.54 (10–19.21)	13.00 (6.46)	12.77 (8–16)
Average Observed Dose (mg per day)	12.93 (7.07)	12.35 (7.81–16.58)	14.61 (6.80)	14.93 (9.32–19.02)	12.41 (7.08)	11.79 (7.33–16)

PDC=Proportion of days covered; MPR=medication possession ratio; mg=milligrams.

^*Among them, 627 patients died before the drug course end.

^**censored for patients who died during the drug course