Extended Data Table 2 |.

Baseline and post-treatment neuroimaging outcomes

Brain Region (voxels)	Baseline Mean (SD)	Post-Treatment Mean (SD)	T-test(df), p-value, 95% CI
Intracerebroventricular Volume (ICV)	1393962.33 (151287.55)	1393461.27 (149379.55)	t(3)=0.150, p=0.89, −11126 – 10124
Total Brain Volume/ICV	0.856 (0.005)	0.851 (0.009)	t(3)=1.732, p=0.18, −0.015 – 0.0042
Grey Matter Volume/ICV	0.359 (0.021)	0.359 (0.015)	t(3)=0.522, p=0.64, −0.018 – 0.013
White Matter Volume/ICV	0.452 (0.006)	0.446 (0.009)	t(3)=1.192, p=0.32, −0.028 – 0.013
Right Hippocampus Volume/ICV	0.002 (0.00016)	0.0002 (0.00013)	t(3)=0.472, p=0.67, −0.00012 – 0.000087
Left Hippocampus Volume/ICV	0.002 (0.00008)	0.002 (0.00012)	t(3)=0.313, p=0.77, −0.000084 – 0.000069

Baseline to post-treatment changes were assessed using two-sided paired samples t-tests, 95% CI: 95 percent confidence interval for the post vs. pre mean difference, p<0.05. No correction for multiple comparisons was made due to small sample size (N=4). Brain regions normalized to intracerebroventricular volume (IVC) measured in voxels.