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. 2024 Feb 19;26:29. doi: 10.1186/s13058-024-01788-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Increased glycolysis correlates with NAC resistance in patient-derived TNBC clinical specimens. A Schematic representation of the clinical workflow for collection of diagnostic biopsies from patients with early-stage TNBC treated with NAC, recruited in this study. B RNA-sequencing datasets, from early TNBC human patients, used for gene set enrichment analysis (GSEA) between responders (RCB 0/I) and non-responders (RCB II/III) to NAC. C–F Pathways significantly up- and down-regulated (C, E) and individual enrichment plots for glycolysis hallmark (D, F) from GSEA of RNA-seq data in NAC-responding and non-responding TNBC specimens (GSE240671 and GSE123845 datasets for C, D and E, F panels, respectively)