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. 2024 Feb 19;24:233. doi: 10.1186/s12885-024-11892-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Inhibition of the p90RSK pathway with BI-D1870 reverses cisplatin resistance in HN30-R8 cells in vitro. (A and B) Cell proliferation assay at 72 h to determine EC50 values for BI-D1870 in the indicated cisplatin resistant cells and corresponding parental cell line. Representative graphs from one experiment are shown. (C) Table indicating average EC50 value for BI-1870. Statistical significance was calculated using Student’s t-test. *p < 0.05. (D) Viability of HN30-R8 cells treated with cisplatin and BI-D1870. Black asterisks compare the viability of cells with and without BI-D1870 within cisplatin treatments. Statistical significance was calculated using two-way ANOVA with Sidak’s multiple comparison test. ***p < 0.0001. Red asterisks compare the viability of cells treated with BI-D1870 alone to cells treated with cisplatin and BI-D1870. Statistical significance was calculated using two-way ANOVA with Tukey’s multiple comparison test. ***p < 0.05