Fig. 4.

TMEM16A expression is correlated to p90RSK activation in cisplatin resistant HNSCC. (A) Representative western blot of indicated cell lines displaying basal expression of TMEM16A and phosphorylated p90RSK. (B) Dot plots quantifying protein expression of phosphorylated p90RSK and corresponding levels of TMEM16A expression. Dot plots from one representative experiment are shown. Statistical significance was calculated using Mann-Whitney test. *p < 0.05. (C) Western blots of indicated cell lines with modified TMEM16A expression and resultant phosphorylated p90RSK expression. Fold changes of band intensities for respective protein is placed above the blot. For A and C, representative blots from one experiment are shown