Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 19;24:233. doi: 10.1186/s12885-024-11892-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — TMEM16A expression is a predictive marker for the efficacy of cisplatin and BI-D1870 combination in vitro. (A) Combination index (CI) values of indicated cell lines treated with increasing concentrations of cisplatin and BI-D1870 at a fixed ratio. CI less than 1.0 (green) indicates synergy, CI between 1.0 and 2.0 (yellow) indicates additivity, and CI greater than 2.0 (grey) indicates antagonism. This experiment was done twice. Data shown is the result of one experiment. (B-E) Viability of indicated cell lines treated with increasing concentrations of cisplatin with and without BI-D1870. Graphs from one representative experiment are shown. Comparisons are made between groups representing viability of cells with and without BI-D1870 within cisplatin treatments. Statistical significance was calculated using two-way ANOVA with Sidak’s multiple comparison test. *p < 0.05, **p 0.001, ***p < 0.0001