Table 1.
Demographic and clinical characteristics of neonates with central venous catheters, with and without bloodstream infection, in three tertiary care neonatal intensive care units in Pune, India, May 1, 2017 - July 31, 2019
| Neonates without BSI n = 1311 |
Neonates with BSI n = 131 |
Total n = 1442 |
|
|---|---|---|---|
| Pregnancy and birth characteristics | |||
| Maternal age in years, median (IQR) | 25 (22–30) | 26 (23–29) | 25 (22–30) |
| Male sex, n (%) | 788 (60.1) | 72 (55.0) | 860 (59.6) |
| Multiple gestation, n (%) | 235 (17.9) | 26 (19.8) | 261 (18.1) |
| Gestational age in weeks, median (IQR) | 32 (29–36) | 31 (28–34) | 32 (29–36) |
| Preterm (<37 weeks), n (%) | 970 (78.3) | 107 (87.0) | 1077 (79.1) |
| Extremely preterm (<28 weeks), n (%) | 166 (13.4) | 25 (20.3) | 191 (14.0) |
| Very preterm (28–31 weeks), n (%) | 428 (34.5) | 44 (35.8) | 472 (34.7) |
| Moderate to late preterm (32–36 weeks), n (%) | 376 (30.3) | 38 (30.9) | 414 (30.4) |
| Term (≥37 weeks) | 269 (21.7) | 16 (13.0) | 285 (20.9) |
| Birth weight in grams, median (IQR) | 1358 (1030–2200) | 1250 (1000–1726) | 1340 (1020–2150) |
| ELBW (<1000 g) | 259 (19.9) | 32 (24.4) | 291 (20.3) |
| VLBW (1000–1499 g) | 467 (35.8) | 52 (39.7) | 519 (36.2) |
| LBW (1500–2499 g) | 336 (25.8) | 34 (26.0) | 370 (25.8) |
| Non-LBW (≥2500 g) | 242 (18.6) | 13 (9.9) | 255 (17.8) |
| Inborn, n (%) | 1157 (88.3) | 115 (87.8) | 1272 (88.2) |
| Cesarean delivery, n (%) | 675 (52.7) | 69 (53.9) | 744 (52.8) |
| PPV at delivery, n (%) | 427 (34.4) | 40 (32.0) | 467 (34.1) |
| NICU course and disposition | |||
| Mechanical ventilation on admission, n (%) | 486 (37.1) | 52 (39.7) | 538 (37.3) |
| Antibiotic administration on admission, n (%) | 983 (75.0) | 107 (81.7) | 1090 (75.6) |
| Duration of CVC presence in days, median (IQR) | 6 (4–9) | 11 (7–17) | 6 (4–9) |
| Length of stay in days, median (IQR) | 16 (8–33) | 24 (12–41) | 16 (8–32) |
| Died, n (%) | 310 (23.6) | 53 (40.5) | 363 (25.2) |
Data not available for all neonates for select variables. Denominator for presented data by variable are as follows (without BSI, with BSI, total presented for each): Maternal age 1129, 110, 1239; gestational age 1239, 123, 1362; birth weight 1304, 131, 1435; delivery mode 1275, 133, 1408; PPV at delivery 1243, 125, 1368. Abbreviations: BSI – bloodstream infection; CVC – central venous catheter; ELBW – extremely low birth weight; IQR – interquartile range; LBW – low birth weight; NICU – neonatal intensive care unit; PPV – positive pressure ventilation; VLBW – very low birth weight.