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. Author manuscript; available in PMC: 2024 Feb 23.
Published in final edited form as: Nature. 2023 Aug 23;620(7976):1101–1108. doi: 10.1038/s41586-023-06441-6

Fig. 5 |. Proposed mechanism of OPA1-mediated mitochondrial IM fusion.

Fig. 5 |

Human L-OPA1 molecules embedded on the surface of the mitochondrial IM may nucleate helical polymerization of MIL-embedded S-OPA1 to drive IM tubulation. Subsequent conformational changes within the OPA1 lattice extract the PD, further constricting the IM and introducing lipid-packing defects to lower the energy barrier to fusion. The diagram was created using BioRender.