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. Author manuscript; available in PMC: 2024 Feb 19.
Published in final edited form as: J Phys Chem B. 2023 May 18;127(21):4746–4760. doi: 10.1021/acs.jpcb.3c01619

Fig. 7. The AFRC enables an expected contract fraction to be calculated, such that normalized contact frequencies can be easily calculated for simulations.

Fig. 7

Across the nine different simulated disordered proteins, we computed the contact fraction (i.e., the fraction of simulations each residue is in contact with any other residue) and divided this value by the expected contact fraction from the AFRC model. This analysis revealed subregions within IDRs that contribute extensively to intramolecular interactions, mirroring finer-grain conclusions obtained in Fig. 6.