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. 2023 Oct 17;33(12):1155–1171. doi: 10.1093/glycob/cwad085

Table 1.

IC50 and IC70 values for fucosylation inhibitors calculated by AAL lectin flow cytometry.

Compound IC50 PC3 IC50 CWR22RV1 IC70 PC3 IC70 CWR22RV1
DMSO N.I N.I N.I. N.I.
A2FF1P 16.26 7.575 29.43 21.15
B2FF1P 26.92 12.86 48.73 31.86
2FF 113.5 25.68 207.0 63.79
Fucotrim I 0.1510 N.D. 0.7560 N.D.
Fucotrim II 29.17 26.96 N.D. N.D.

N.I = no inhibition. N.D = not determined since the measured values did not reach a reduction to 50% respectively 70% in lectin binding.