Fig. 3. Treatment efficacy of CPMV hydrogels. (A) Treatment and tumor injection schedule. The groups are PBS (n = 8), Sham hydrogel (n = 9), CPMV hydrogel (900 μg + 100 μg soluble CPMV) (n =9), bolus treatment (1 mg CPMV) (n = 9), and weekly CPMV dosing using 100 μg (n = 10). (B) Individual circumferences in each group. (C) Average body circumferences for all treatment groups. Data points are cut off when n < 5 for the treatment group. (D) Survival rates for all treatment groups. Statistical significance in (C) was calculated by two-way ANOVA (**p < 0.01, ***p < 0.001, ****p < 0.0001). Statistical significance in (D) was calculated using the log-rank (Mantel–Cox) test (**p < 0.01, ****p < 0.0001).