Table 2.
Number of Traits Significantly Associated with Each Age-associated SASP
| Gene symbol* | Number significant** | Traits associated*** | Proportion significant |
|---|---|---|---|
| IGFBP2 | 8 | Waist circumference, glucose, CRP, diastolic BP, albumin, RDW, grip strength, systolic BP | 0.67 |
| GDF15 | 7 | Gait speed, grip strength, BUN, IL6, glucose, albumin, RDW | 0.58 |
| CST3 | 5 | Gait speed, IL6, albumin, grip strength, BUN | 0.42 |
| SERPING1 | 3 | Waist circumference, CRP, IL6 | 0.25 |
| YWHAZ | 3 | Gait speed, waist circumference, grip strength | 0.25 |
| TIMP1 | 3 | RDW, IL6, gait speed | 0.25 |
| CTSZ | 3 | Waist circumference, CRP, gait speed | 0.25 |
| LAMB1 | 2 | Diastolic BP, waist circumference | 0.17 |
| POSTN | 2 | Gait speed, waist circumference | 0.17 |
| TIMP2 | 2 | CRP, waist circumference | 0.17 |
| STC1 | 2 | BUN, IL6 | 0.17 |
| ALDOA | 2 | Gait speed, IL6 | 0.17 |
| BGN | 1 | Glucose | 0.08 |
| CLEC11A | 1 | RDW | 0.08 |
| CLIC1 | 1 | Gait speed | 0.08 |
| ECM1 | 1 | CRP | 0.08 |
| IGFBP7 | 1 | Albumin | 0.08 |
| PGAM1 | 1 | Gait speed | 0.08 |
Notes: BP = blood pressure; BUN = blood urea nitrogen; CRP = C-reactive protein; IL6 = Interleukin-6; RDW = red cell distribution width.
*Includes only age-associated SASP with at least 1 significant trait association.
**Significant after Bonferroni correction.
***Traits listed in order of increasing trait association p value.