Table 3.
Traits Enriched for SASP Associations
| Trait | Number significant* | Gene symbols of proteins significantly associated** | Enrichment p Value*** |
|---|---|---|---|
| Usual gait speed | 9 | GDF15, CST3, PGAM1, YWHAZ, CLIC1, POSTN, ALDOA, CTSZ, TIMP1 | 0.17 |
| Waist circumference | 7 | IGFBP2, TIMP2, CTSZ, SERPING1, POSTN, LAMB1, YWHAZ | 0.0081 |
| Log IL-6 | 6 | GDF15, CST3, STC1, TIMP1, SERPING1, ALDOA | 0.0014 |
| Log CRP | 5 | IGFBP2, TIMP2, CSTZ, ECM1, SERPING1 | 0.51 |
| Grip strength | 4 | GDF15, IGFBP2, CST3, YWHAZ | 0.17 |
| RBC distribution width | 4 | IGFBP2, TIMP1, CLEC11A, GDF15 | 0.010 |
| Albumin | 4 | IGFBP2, IGFBP7, CST3, GDF15 | 0.076 |
| Log glucose | 3 | IGFBP2, GDF15, BGN | 0.020 |
| Blood urea nitrogen | 3 | GDF15, STC1, CST3 | 0.19 |
| Diastolic BP | 2 | IGFBP2, LAMB1 | 0.54 |
| Systolic BP | 1 | IGFBP2 | 0.52 |
Notes: BP = blood pressure; CRP = C-reactive protein; IL6 = Interleukin-6; RBC = red blood cells.
*Bonferroni p value ≤ .05, of the 28 age-associated SASP proteins.
**Gene symbols listed in order of increasing trait association p value.
***Fisher’s exact test comparing the proportion of nominally significant SASP-trait associations among the 28 age-associated SASP proteins with the proportion of nominally significant trait associations among all 1 269 non-SASP proteins represented on SomaScan panel.