Table 1.
Study characteristics
| Reference number | Author | Year | Title | TSD (years) | Methodology | Location | Sample style (n =) | Study design | Controls/comparison sample | Study aims | Instrument | Clinical significance cut off | Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 19 | Kangas, Williams and Smee | 2011 | Benefit finding in adults treated for benign meningioma brain tumour patients: relations with psychosocial wellbeing | 4.4 years | Quantitative | Australia | Benign meningioma patient sample (n = 70) | Cross-sectional observational | N/A | Investigate the association between BF and demographic and psychosocial variables | -Profile of Mood States Subscales: - -Impact of Event Scale |
->7 [S.R 11] -N/A |
Radiation -One course of radiation (“Early subgroup”: 85%; “Late” subgroup: 44%) -Multiple treatments (“Early subgroup”: 15%; “Late” subgroup: 56%) |
| 13 | Van der vossen, schepers, van der sprenkel, vissermeily, post | 2014 | Cognitive and emotional problems in patients after cerebral meningioma surgery | 32.6 months (postoperative) | Quantitative | The Netherlands | Patients operated on for a cerebral meningioma (n = 194) | Cross-sectional observational | N/A | Determine long-term cognitive complaints an symptoms of depression or anxiety in patients following surgery and related factors | -Cognitive Failures Questionnaire -HADS |
-N/A ->11 |
- Neurosurgery |
| 20 | Najafabadi; van der Meer, Boele, Taphoorn, Klein, Peerdman, van Furth, Dirven | 2020 | Determinants and predictors for the long-term disease burden of intracranial meningioma patients | 10 years since diagnosis | Quantitative | The Netherlands | WHO Grade I/II meningioma (n = 190) | Cross-sectional observational | N/A | Assess the determinants for long-term disease burden, defined as impaired HRQOL and neurocognitive functioning | -surveys- 36 | -N/A | -Mixed (surgery as initial treatment: 88%; radiotherapy as initial treatment: 5%) |
| 21 | Niewenhuizen, Klein, Stalpers, Leenstra, Heimans, Reijneveld | 2007 | Differential effect of surgery and radiotherapy on neurocognitive functioning and health-related quality of life in WHO grade I meningioma | Surgery only group: 3 years Surgery + RT: 7.6 years |
Quantitative | The Netherlands | WHO Grade I meningioma (n = 18) | Cross-sectional observational | RT group vs. RT + surgery | Quantify the effects of conventional RT vs. RT + surgery | -SF-36 -EORTC BN20 |
-N/A -N/A |
- Neurosurgery - Radiotherapy |
| 16 | Combs, Adeberg, Dittmar, Welzel, Reiken, Habermehl, Huber, Debus | 2013 | Skull based meningiomas: long-term results and patient self-reported out come in 507 patients treated with fractioned stereotactic radiotherapy | 107 months | Quantitative | Germany | Skull-base meningioma patients (n = 340) | Cross-sectional observational | N/A | Evaluate long-term toxicity and QOL as a result of fractionated stereotactic radiotherapy or intensity modulated radiotherapy | -Un-validated questionnaire | -N/A | - Neurosurgery (54%) - Radiotherapy (74%) |
| 22 | Timmer, Seibi-Leven, Wittenstein, Grau, Stravrinou, Rohn, Krishek, Coldbrunner | 2019 | Long-term outcomes and HRQOL of elderly patients after meningioma surgery | 3.8 years | Mixed methods | Germany | Meningioma patients who had undergone surgical resection (n = 133) | Cross-sectional observational | N/A | Assess long-term impairments of HRQOL after meningioma resection in different ages | -SF-36 | -N/A | - Neurosurgery |
| 7 | Zamanipoor, Najafabadi et al | 2021 | Long-term disease burden survivorship issues after surgery and RT of intracranial meningioma patients | (median 9 years) | Quantitative | The Netherlands | Intracranial meningioma patients (n = 190) | Cross-sectional observational | N/A | Assess long-term disease burden in meningioma patients | -SF-36 -HADS -EORTC BN20 -SF-HLQ |
-N/A ->11 -N/A -N/A |
- Neurosurgery (surgery as initial treatment: 88%) - Radiotherapy (radiotherapy as initial treatment: 5%) |
| 23 | Nassiri, price, shehab, Au, Cusimano, Jenkinson, Jungk, Mansouri, Santarius, Suppiah, Teng, Toor, Zadeh, Walbert, Drummond, Internatgional consortium and meningiomas | 2019 | Life after surgical resection of a meningioma: a prospective, cross-sectional study evaluating health-related quality of life | 37 months (first assessment); 47.5 months (all assessments) | Quantitative | Australia | Grade I intracranial meningioma (n = 181) | Longitudinal observational | Normative population | Evaluate possible determinant of changes in global HRQOL | -EORTC QLQ C30 | -90 (functioning domains) -5–10 (symptom domains)24 |
- Neurosurgery |
| 12 | Nassiri, Suppiah, Wang, Badhivala, Juraschua, Meng, Nejad, Au, Willmarth, Cusimana & Zadeh | 2020 | How to live with a meningioma: experiences, symptoms and challenges reported by patients | 3 years (19.4%) 5 years (39.4%) |
Quantitative | Canada | Meningioma patients (83%) (n = 1852) | Cross-sectional observational | N/A | Explore the gaps in care of meningioma patients that would improve quality of care by better understanding | - 19-item self-report questionnaire from American Brain Tumour Association | -N/A | - Neurosurgery (65.5%) - Radiotherapy (28.3%) - Chemotherapy (3.8%) |
| 11 | Najafabadi et al., | 2019 | Unmet needs and recommendations to improve meningioma care through patient, partner and health care provider input: a mixed method study | (median) 66 months | Mixed methods | The Netherlands | Suspected or confirmed Grade I or II meningioma patients (n = 16) | Cross-sectional observational | N/A | Evaluate the current structure and issues faced by meningioma patients | - Semistructured interviews | -N/A | - Neurosurgery: (92%) - Radiotherapy: (25%) |
| 25 | Zamanipoor Najafabadi et al., | 2018 | The disease burden of meningioma patients: long-term results on work productivity and healthcare consumption | (median) 10 years | Quantitative | The Netherlands | Meningioma patients (n = 106) | Cross-sectional observational | N/A | Impact of short and long-term neurological sequalae and HRQOL impairments on work productivity | -SF-HLQ | -N/A | - Neurosurgery |
| 26 | Kangas, Williams, Snee | 2012 | The association between posttraumatic tress and health related quality of life in adults treated for benign meningioma | 4.4 years | Mixed methods | Australia | Meningioma patients previously treated with radiotherapy (n = 70) | Cross-sectional observational | N/A | Objective investigate the incidence of MGM-related PTSS in patients who had been diagnosed and treated for primary benign MGM | -Impact of Event Scale Revised -FACT -Profile of Mood States -Semistructured interviews |
-≥33 -N/A -≥7 -N/A |
-One course of radiation: 60% -Multiple treatments: 40% |
| 27 | Baba, McCradden, Rabski, Cusimano | 2019 | Determining the unmet needs of patients with intracranial meningioma—a qualitative assessment | 10 years | Qualitative | Canada | Patients with intracranial meningioma (n = 50) | Cross-sectional observational | N/A | Determine the unmet needs of patient with intracranial meningioma | -Semistructured interviews | -N/A | - Neurosurgery (96.6%) - Radiotherapy [before surgery: (3.3%); after surgery (20%)] |
| 28 | Pintea, Kandenwein, Lorenzen, Bostrom, Daker, Velazquez, Kristof | 2018 | Factors of influence upon the SF-36 based HRQOL of patients following surgery for petroclival and lateral posterior surface of pyramid meningiomas | 59 months (postoperative) | Quantitative | Germany | Patients operated on for petroclival meningioma or lateral posterior surface of pyramid meningiomas (n = 78) | Cross-sectional observational | “Normal” population means | To describe the patient’s self-assessed HRQOL | -SF-36 | -N/A | - Neurosurgery - Radiotherapy (15%) |
| 29 | Kalascuskas, Kerc, Ajaj van Cube, Ringel, Renovanz | 2020 | Psychological burden in meningioma patients under a wait-and-watch strategy and after complete resection is high results of a prospective single centre study | 39 months | Quantitative | Germany | Meningioma patients under a wait-and-watch strategy or no neurologic deficits after complete resection (n = 62) | Cross-sectional experimental | N/A | Compare the psychosocial situation of meningioma under a wait and watch strategy to those who had undergone complete resections | -Distress Thermometer -HADS -BFI -SF-36 |
-> 3 ->11 -1-3 (mild); 4-7 (moderate) 8-10 (severe) -N/A |
- “Wait-and-watch” strategy - Neurosurgery |
| 18 | Tanti, Marsch, Jenkinson | 2017 | Epilepsy and adverse quality of life in surgically resected meningioma | 3.9 years (median, time since surgery) | Quantitative | United Kingdom | Patients who had undergone surgical resection for supratentorial WHO grade I meningioma (n = 229) | Cross-sectional observational | N/A | Comparing HRQOL between MGM patients with and without epilepsy and between epilepsy patients with/without | -FACT-BR -LAEP |
->7 ->45 of total LAEP score or > 8 of the number of severe LAEP items |
- Neurosurgery |
| 14 | Kalkanis, Quinones-Hinojosa, Buzney, Ribaudo, Blac | 2000 | Quality of life following surgery for intracranial meningiomas at Brigham and Women’s Hospital: a study of 164 patients using a modification of the functional assessment of cancer therapy-brain questionnaire | 33 months (mean), 28 months (median) | Qualitative | United States | Patients who had undergone craniotomy for resection of an intracranial meningioma (n = 155) | Cross-sectional observational | N/A | Determine the reported QOL of patient with meningioma that had been surgically treated | Standardized QOL questions modified from the FACT-BR | ->7 | - Neurosurgery |
| 30 | Zamanipoor Najafabadi, van der Meer, Boele, Reijneveld, Taphoorn, Klein, van Furth, Dirven, Peerdema | 2018 | The long-term disease burden of meningioma patients: results on health-related quality of life, cognitive function, anxiety and depression | 9.9 years (median) | Quantitative | The Netherlands | Intracranial meningioma patients after antitumor therapy (n = 164) | Multicenter cross-sectional observational | Newly diagnosed glioblastoma patients | Assess the long-term disease burden of meningioma patients | -SF-36 -EORTC QLQ BN20 -HADS |
-N/A -N/A ->11 |
- Neurosurgery: 89.2%, radiotherapy: 14.6% |
| 15 | Pettersson-Segerlind, Fletcher-Sandersjoo, von Vogelsang, Peresson, Kihlstrom, Linder, Forander, Mathiesen, Edstrom, Elmi-Terander | 2022 | Long-Term Follow-Up, Treatment Strategies, Functional Outcome, and Health-Related Quality of Life after Surgery for WHO Grade 2 and 3 Intracranial Meningiomas | 13 years (grade II) 1.4 years (grade III) |
Mixed methods | Sweden | WHO Grade 2 and 3 meningioma patients surgically treated (n = 51 [12–13 patients for the HRQOL measures]; 43 Grade 2, 8, Grade 3) | Population-based, observational, cross-sectional cohort study | N/A | Determine the HRQOL of long-term progression-free survival and overall survival for WHO Grade 2 and 3 intracranial meningiomas | -EQ-5D-3L -FACT-BR -HADS, structured interviews |
• GAD-2: >3 • PHQ-9: > 10 (mild); >15 (moderate to severe) -> 7 -> 11 |
- Neurosurgery |
| 31 | Pettersson-Segerlind, von Vogelsang, Fletcher Sandersjoo, Tatter, Mathiesen, Edstrom, Elmi Terander | 2021 | Health-Related Quality of Life and Return to Work after Surgery for Spinal Meningioma: A Population-Based Cohort Study | 8.7 years (mean) | Quantitative | Sweden | Spinal meningioma surgically treated (n = 84) | Population-based observational cohort study | General population | Assess the HRQOL and the frequency of return to work in patients surgically treated for spinal meningiomas compared to the general population | -EQ-5D-3DL | -GAD-2: >3 -PHQ-9: > 10 (mild); >15 (moderate to severe) |
- Neurosurgery |
| 17 | Fisher, Najafabadi, van der Meer, Boele, Peerdeman, Peul, Taphoorn, Dirven, van Furth | 2022 | Long-term health-related quality of life and neurocognitive functioning after treatment in skull base meningioma patients | 9 years (median) | Quantitative | The Netherlands | Skull base meningioma (n = 89) | Cross-sectional | Convexity meningioma patients and informal caregivers of skull base meningioma patients | Assess the long-term HRQOL and neurocognitive functioning after treatment in the long term | -SF-36, -EORTC QLQ-BN20 |
-N/A -N/A |
- Radiotherapy vs. neurosurgery |
Abbreviations: BFI, Brief Fatigue Inventory; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30; EORTC BN20, European Organisation for Research and Treatment of Cancer BN20 Brain Tumour module; EQ-5D-3L, 3-level version of EQ-5D; FACT, Functional Assessment of Cancer Therapy; FACT-BR, Functional Assessment of Cancer Therapy-Brain; GAD-2, Generalized Anxiety Disorder-2; HADS, Hospital Anxiety and Depression scale; HRQOL, health-related quality of life; LAEP, Liverpool Adverse Events Profile; N/A, not applicable; PHQ, Patient Health Questionnaire; SF-36, Short Form-36; SF-HLQ,Short Form—Health and Labour Questionnaire; WHO, World Health Organization.