TABLE 1.

Model-fitted parameter estimates and magnitude of the fAUC_0-24/MIC and fC_max/MIC ratios producing 90, 95, and 99% E_max

Model-fitted parameter	fAUC0-24/MICa	fCmax/MICa
Emax	−3.58 (−4.1, −3.0)	−3.80 (−4.5, −2.8)
Hill's constant	2.04 (1.2, 2.8)	1.39 (0.7, 2.4)
IC50b	34.7 (27.0, 43.1)	2.61 (1.6, 3.9)
90% Emax	105	12.7
95% Emax	152	21.7
99% Emax	348	71.2

^aData are reported as maximum likelihood parameter estimates (Wald 95% confidence intervals are shown in parentheses).

^bIC₅₀, 50% inhibitory concentration.