TABLE 2.

Relationship between mutations in the QRDRs of the gyrA genes and the MICs for C. amycolatum

Straina	GyrA (aa) sequenceb					MIC (μg/ml)c
	87-S	88-A	89-I	90-Y	91-D	CIP	LEV	MOX
1008	S	A	I	Y	D	0.064	0.094	0.016
1186	S	A	I	Y	D	0.047	0.094	0.016
1049	R	A	I	Y	D	>32	8	2
1011	R	A	V	Y	D	>32	24	6
1009	R	P	I	Y	D	>32	>32	>32
1028	R	P	I	Y	D	>32	>32	>32
1044	R	P	I	Y	D	>32	>32	>32
1067	R	P	I	Y	D	>32	>32	>32
1189	R	P	I	Y	D	>32	>32	>32
CA1*	R	A	I	Y	D	>32	8	2
CA32A*	R	P	I	Y	D	>32	>32	>32
CA32B*	R	A	I	Y	Y	>32	>32	>32
CA32C*	R	P	I	Y	D	>32	>32	>32

^a*, In vitro fluoroquinolone-resistant mutants.

^baa, amino acid.

^cCIP, ciprofloxacin; LEV, levofloxacin; MOX, moxifloxacin.