TABLE 1.
Inhibitory activity and cytotoxic effect of nucleosides in replicon cell-based assay
| Compound | Replicon IC50 (μM)a of cell type at:
|
Toxicity (CC50 [μM]) of cell type at 72 h
|
||||||
|---|---|---|---|---|---|---|---|---|
| 24 h
|
48 h
|
72 h
|
||||||
| HBI10A | HBIII27 | HBI10A | HBIII27 | HBI10A | HBIII27 | HBI10A | HBIII27 | |
| 2′-C-Me-A | 0.3 ± 0.1 | 0.5 ± 0.2 | 0.2 ± 0.1 | 0.3 ± 0.1 | 0.1 ± 0.01 | 0.3 ± 0.1 | 100 | 33 |
| 2′-O-Me-C | 21.0 ± 1.8 | >100 | 12.0 ± 0.9 | >100 | 11.0 ± 0.4 | >100 | >100 | >100 |
a
The IC50 is the average ± standard deviation of the results from at least three determinations.