. 2005 May;49(5):1994–2001. doi: 10.1128/AAC.49.5.1994-2001.2005

TABLE 2.

Activity of cyclo-d4G against common resistant forms of HIV-1 Bru Pitt. in PBM cells

Virus	Anti-HIV activity (μM)^a		FI₅₀^b	FI₉₀^b	n
Virus	EC₅₀	EC₉₀	FI₅₀^b	FI₉₀^b	n
Bru Pitt.	4.4 ± 3.7	19 ± 12			6
K65R	19 ± 10	>100	4	>5	2
L74V	9.6 ± 1.5	74 ± 19	2	4	3
M184V	2.2 ± 1.3	11 ± 3	0.5	0.6	3
4× AZT^c	1.4 ± 0.9	34 ± 19	0.3	2	3

Values represent means ± SD for n experiments.

FI₅₀ = EC₅₀^Mutant/EC₅₀^{Bru Pitt.}. FI₉₀^Mutant/EC₉₀^{Bru Pitt.}.

4× AZT contains RT mutants K67N, K70R, T215Y, and K219Q.