TABLE 5.
Effect of mycophenolic acid on NRTI anti-HIV-1 IIIB activity in MT-2 cells
| NRTI | Anti-HIV-1 IIIB (μM)a
|
FI50c | n | |
|---|---|---|---|---|
| EC50 | EC50 + mycophenolic acid | |||
| CBV | 0.71 ± 0.41 | 0.090 ± 0.014 | 8 | 3 |
| ddI | 9.1 ± 5.5 | 1.75 ± 0.35 | 5 | 3 |
| DAPD | 9.7 ± 2.1 | 3.5 ± 2.2 | 3 | 3 |
| ABC | 2.4 ± 1.2 | 2.8 ± 1.0 | 1 | 2 |
| d4G | 4.5 ± 0.7 | 5.1 ± 1.3 | 1 | 2 |
| Cyclo-d4G | 8.3 ± 1.5 | 23 ± 8b | 0.4 | 3 |
a
Values represent means±SD for n independent experiments done in triplicate.
b
Activity with the addition of 10 μM guanine in addition to mycophenolic acid was 6.8 ± 1.0 (mean±SD of three independent experiments done in triplicate).
c
FI50 = EC50/(EC50 + mycophenolic acid). Values represent the means of n experiments done in triplicate.