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Effect of deaminase inhibitors on anti-HIV-1 IIIB activity in MT-2 cells
| Compound | MT-2 (IIIB)a
|
|
|---|---|---|
| EC50 | IC50 | |
| d4G | 6.3 ± 1.8 | 40 ± 7 |
| d4G + EHNA | 9.8 ± 3.2 | 21 ± 1 |
| d4G + dCF | 8.0 ± 2.8 | 39 ± 9 |
| Cyclo-d4G | 11 ± 1 | 87 ± 2 |
| Cyclo-d4G + EHNA | 14 ± 6 | 53 ± 4 |
| Cyclo-d4G + dCF | >100 | 85 ± 7 |
Values represent means±SD of two independent experiments done in triplicate.
