Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effects of nucleoside analogs on Neuro 2A cellsa
| Nucleoside | IC50 (μM) | Concn (μM) | Lactate (mg/106 cells) | Mitochondrial DNA (% control) |
|---|---|---|---|---|
| No drug | 9.9 ± 0.7 | 100 ± 30 | ||
| Cyclo-d4G | 140 ± 6 | 1 | 10 ± 0.3 | 110 ± 4 |
| 10 | 11 ± 0.4 | 112 ± 33 | ||
| 100 | 12 ± 1 | 81 ± 12 | ||
| d4T | 225 ± 8 | 1 | 11 ± 1 | 95 ± 18 |
| 10 | 13 ± 1 | 84 ± 15 | ||
| 100 | 14 ± 1 | 37 ± 11 | ||
| ddC | 6.0 ± 0.2 | 0.01 | 11 ± 0.4 | 150 ± 40 |
| 0.1 | 12 ± 0.5 | 108 ± 13 | ||
| 1 | 15 ± 0.2 | 96 ± 8 |
Values represent means ± SD of triplicate wells.
